Leena Mallik, PhD

Leena Mallik, PhD

Research Associate II

Trained as a protein biochemist and structural biologist with experience in various biochemical and biophysical methodologies including x-ray crystallography, electron microscopy and small-angle X-ray scattering.

I pursue my Ph.D. from protein science and engineering division at Institute of Microbial Technology (IMTECH), Chandigarh, India under the supervision of Dr Ashish.  During Ph.D., I studied the structure-function relationship of two kidney protein (Neph1 and ZO-1), which are critical for human kidney function, using small-angle X-ray scattering and biochemical approaches. Following that, I joined University of Michigan as a post-doctoral fellow where I got an opportunity to work in a multidisciplinary environment. In addition, I received training on high-resolution methods such as electron microscopy and X-ray crystallography under the supervision of Prof. Markos Koutmos and Prof. Yiorgo Skiniotis. During my post-doctoral training I worked on receptor (Leptin Receptor), RNase P and DNA Origami, where I utilized electron microscopy and X-ray crystallography to study structure-function relation. Moving forward, I joined Centre for Structure Biology, Life Science Institute, University of Michigan as a Research Investigator, where I worked on early-stage drug discovery projects and X-ray crystallography been primarily used to understand the protein-small molecule/ligand interactions.

Currently, at Sgourakis lab my main focus includes understanding the antigen processing and presentation by MHC molecules. Structural insight into the assembly of MHC and antigen peptide and to understand the molecular dynamics.