Decoding immune function at the atomic level
Research at the Sgourakis Lab sheds light on the dynamic molecular processes which determine immune recognition, signaling and the formation of long-term memory against viral, tumor and autoimmune targets.
To address these questions, we integrate cutting-edge structural biology tools, such as Nuclear Magnetic Resonance (NMR) Spectroscopy and X-ray crystallography, with complementary biophysical and biochemical techniques, computational modeling, and functional assays. The Sgourakis Lab’s efforts are done in close collaboration with the vibrant research community at the Children’s Hospital of Philadelphia (CHOP) and the University of Pennsylvania.
We are affiliated with:
Sun Y, Florio TJ, Gupta S, Young MC, Marshall QF, Garfinkle SE, Papadaki GF, Truong HV, Mycek E, Li P, Farrel A, Church NL, Jabar S, Beasley MD, Kiefel BR, Yarmarkovich M, Mallik L, Maris JM, Sgourakis NG. Sci Immunol. 2023 Dec 1. doi: 10.1126/sciimmunol.adj5792.
Gupta S, Nerli S, Kutti Kandy S, Mersky GL, Sgourakis NG. Nat. Commun. 2023 Oct 10. doi: 10.1038/s41467-023-42163-z.
Sun Y, Young MC, Woodward CH, Danon JN, Truong HV, Gupta S, Winters TJ, Font-Burgada J, Burslem GM, Sgourakis NG. Proc. Natl. Acad. Sci. U.S.A. 2023 Jun 20. doi: 10.1073/pnas.2304055120.