Decoding immune function at the atomic level
Research at the Sgourakis Lab sheds light on the dynamic molecular processes which determine immune recognition, signaling and the formation of long-term memory against viral, tumor and autoimmune targets.
To address these questions, we integrate cutting-edge structural biology tools, such as Nuclear Magnetic Resonance (NMR) Spectroscopy and X-ray crystallography, with complementary biophysical and biochemical techniques, computational modeling, and functional assays. The Sgourakis Lab’s efforts are done in close collaboration with the vibrant research community at the Children’s Hospital of Philadelphia (CHOP) and the University of Pennsylvania.
We are affiliated with:
Sun Y, Young MC, Woodward CH, Danon JN, Truong HV, Gupta S, Winters TJ, Font-Burgada J, Burslem GM, Sgourakis NG. Proc Natl Acad Sci U S A. 2023 Jun 20;120(25):e2304055120. doi: 10.1073/pnas.2304055120. Epub 2023 Jun 13.
Yi Sun, Georgia F. Papadaki, Christine A. Devlin, Julia N. Danon, Michael C. Young, Trenton J. Winters, George M. Burslem Erik Procko, and Nikolaos G. Sgourakis, Science Advances 2023, 9: 8
Decoupling peptide binding from T cell receptor recognition with engineered chimeric MHC-I molecules
Papadaki GF, Ani O, Florio TJ, Young MC, Danon JN, Sun Y, Dersh D, Sgourakis Frontiers in Immunology 2023 In Press
The Sgourakis laboratory is grateful to our funding sources:
