Decoding immune function at the atomic level
Research at the Sgourakis Lab sheds light on the dynamic molecular processes which determine immune recognition, signaling and the formation of long-term memory against viral, tumor and autoimmune targets.
To address these questions, we integrate cutting-edge structural biology tools from (NMR) Nuclear Magnetic Resonance Spectroscopy, X-ray crystallography with complementary biophysical and biochemical techniques, computational modeling and functional assays. Sgourakis lab’s efforts are done in close collaboration with the vibrant research community at Children’s Hospital of Philadelphia (CHOP) and the University of Pennsylvania (UPENN).
We are affiliated with:
Decoupling peptide binding from T cell receptor recognition with engineered chimeric MHC-I molecules
Papadaki GF, Ani O, Florio TJ, Young MC, Danon JN, Sun Y, Dersh D, Sgourakis Frontiers in Immunology 2023 In Press
TAPBPR employs a ligand-independent docking mechanism to chaperone MR1 molecules
McShan AC, Devlin CA, Papadaki GF, Sun Y, Green AI, Burslem GM, Prock E, Sgourakis NG Nature Chemical Biology. 2022, 18, pages 859–868
Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs
Yarmarkovich M, Marshall QF, Warrington JM, Premaratne R, Farrel A, Groff D, Li W, di Marco M, Runbeck E, Truong H, Toor JS, Tripathi S, Nguyen S, Shen H, Noel T, Church NL, Weiner A, Kendsersky N, Martinez D, Weisberg R, Christie M, Eisenlohr L, Bosse KR, Dimitrov DS, Stevanovic S, Sgourakis NG, Kiefel BR, Maris JM. Nature. 2021 Nov;599(7885):477-484.
The Sgourakis laboratory is grateful to our funding sources:
