Sreeja Kutti Kandy

Sreeja Kutti Kandy

Postdoctoral Fellow

I am an interdisciplinary researcher trained in computational physics and biology. My primary research interests are in mathematical and statistical modeling of biophysical systems, soft condensed matter systems, and machine learning. I graduated with a PhD in Physics from the Indian Institute of Technology Madras, India. In my graduate thesis, I investigated the role of steric and electrostatic forces due to membrane bound proteins in remodeling of cell membranes.

After graduation, I joined the group of Prof. Ravi Radhakrishnan at the University of Pennsylvania where I had developed multiscale computational models to investigate the role of adhesion proteins and glycocalyx on cell membranes in mediating cancer progression, especially hepatocellular carcinoma. I also developed models for multivalent interactions of different types of nanoparticles at the plasma membrane interface to understand the adhesion and uptake of nanoparticles in targeted drug delivery. In collaboration with experimental researchers I also worked on developing computational methods to study role of actin cytoskeletal in cell mechanics and capillary induced colloidal aggregation at fluid interfaces.

In my present role in the Sgourakis Lab, my work focuses on interactions of the major histocompatibility (MHC)-Class I proteins with its peptide binding partners. I use computational tools for protein structure modeling coupled with machine learning to develop predictive models for peptide-MHC complexes.